产品说明
一般描述
The PTEN (phosphatase and tensin homolog) gene is mapped to human chromosome 10q23. It shares sequence homology with protein tyrosine phosphatases and the cytoskeletal protein tensin.
特异性
The epitope recognized by the antibody resides within amino acids 386-403 of rat PTEN.
免疫原
synthetic peptide corresponding to the C-terminus of rat PTEN (amino acids 386-403).
生化/生理作用
The PTEN (phosphatase and tensin homolog) gene encodes a encodes a dual-specificity phosphatase that functions as a tumor suppressor by inhibiting phosphoinositide-3-kinase–protein kinase B/Akt (PI3K/PKB/Akt) signaling pathway, a crucial regulator of cell growth and survival and by negatively regulating the interactions of cell with the extracellular matrix. Mutations in this gene have been associated with several human cancers. Germline mutations in this gene have also been linked to Cowden disease (CD), Lhermitte-Duclos disease (LDD) and Bannayan-Zonana syndrome (BZS), which are characterized by increased susceptibility to tumor formation and developmental defects.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD02097285 |
| NACRES | NA.41 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | PTN-18, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~55 kDa |
| species reactivity | mouse, rat, human |
| 浓度 | ~1 mg/mL |
| technique(s) | immunocytochemistry: suitable using 4% paraformaldehyde-0.5% Triton X-100 fixation indirect ELISA: suitable microarray: suitable western blot: 5-10 μg/mL using whole extract of rat brain |
| 同位素/亚型 | IgG2a |
| UniProt登记号 | P60484 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... PTEN(5728) mouse ... Pten(19211) rat ... Pten(50557) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
