产品说明
一般描述
Peptide sequence of the antigen is highly conserved in human (single amino acid substitution) and chicken NGFR p75.
Nerve growth factor receptor (NGFR) is encoded by the gene mapped to rat chromosome 10. In rats, immunoreactivity of NGFR has been observed in neuronal cell bodies, axons and/or dendrites of cholinergic and non-cholinergic structures of the brain.
免疫原
synthetic peptide corresponding to the C-terminal of NGFR p75 of rat origin (amino acids 407-425 with N-terminally added lysine) conjugated to KLH.
应用
Anti-Nerve growth factor receptor (NGFR p75) antibody produced in rabbit has been used in:
- immunoprecipitation
- immunocytochemistry
- immunohistochemistry
- immunoblotting
生化/生理作用
Neurotrophins (NT) are growth factors that are essential for the development and maintenance of the nervous system. One of the receptors that mediate the effects of NTs is the Nerve Growth Factor Receptor/TNFRSF16 (p75NGFR, p75NTR). NGFR mediates the effects of NGF that are important in the survival and differentiation of neurons and neural crest-derived cells, during embryonic and early postnatal development. Expression of NGFR has been associated with favorable prognosis and survival in breast and pancreatic cancers.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD00675539 |
| NACRES | NA.41 |
产品性质
| 生物来源 | rabbit |
| 质量水平 | 200 |
| 偶联物 | unconjugated |
| 抗体形式 | affinity isolated antibody |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| species reactivity | rat |
| 增强验证 | functional assay Learn more about Antibody Enhanced Validation |
| technique(s) | immunohistochemistry (frozen sections): 1:10,000 using rat brain indirect immunofluorescence: 1:500 using NGF-treated PC12 cells microarray: suitable western blot: 1:5,000 using whole cell extract of NGF-treated PC12 cells |
| UniProt登记号 | P07174 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | rat ... Ngfr(24596) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
