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Anti-Myosin Va (LF-18) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
M4812
规格纯度
~0.4 mg/mL, affinity isolated antibody, buffered aqueous solution
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Anti-myosin Va (LF-18) recognizes myosin Va (190kDa). Myosin 5a is encoded by the gene mapped to human chromosome 15q21.2. The encoded protein is a member of the unconventional myosin family. It is a two-headed motor containing two identical heavy chains and multiple light chains. Myosin Va is widely expressed, but at high levels in the brain, testes and melanocytes.

免疫原

synthetic peptide located near the C-terminus of chicken myosin Va (amino acids 1782-1799 with N-terminally added lysine) conjugated to KLH. This sequence is identical in human, mouse and rat.

应用

Anti-Myosin Va (LF-18) antibody produced in rabbit has been used in:

  • Western blot.
  • In situ proximity ligation assay (PLA).
  • Glutathione S-transferase (GST)-spinophilin co-sedimentation assay.

生化/生理作用

Myosin 5a is an actin-based molecular motor responsible for transport of secretory granules in various cell systems, including insulin granule. Additionally, it also mediates the transport of cargo such as cell-surface receptors, pigment and organelles like endoplasmic reticulum to the plasma membrane. The encoded protein facilitates pigmentation and synaptic activity in the central nervous system. Genetic variations in the gene are associated with the development of immunological and neurological diseases, including Griscelli syndrome type 1 and Elejalde syndrome.

外形

Solution in 0.01 M phosphate buffered saline containing 1% BSA and 15 mM sodium azide.

储存及稳定性

For continuous use, store at 2-8℃ for up to one month. For prolonged storage, freeze in working aliquots at -20℃. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilution samples should be discarded if not used within 12 hours.

其他说明

In order to obtain best results in different techniques and preparations we recommend determining optimal working dilutions by titration test.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD03455613
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous solution
分子量antigen 190 kDa
species reactivityrat, chicken
浓度~0.4 mg/mL
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:200 using rat and chicken cerebellum sections
microarray: suitable
western blot: 1:1,000 using a rat brain extract
UniProt登记号Q02440
运输dry ice
储存温度−20℃
Gene Informationhuman ... MYO5A(4644)
mouse ... Myo5a(17918)
rat ... Myo5a(25017)

安全信息

储存分类代码12 - Non Combustible Liquids
WGKnwg
闪点(F)Not applicable
闪点(C)Not applicable

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