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TFIIH, native complex human

品牌
Sigma-Aldrich
货号
SRP2010
规格纯度
≥75% (SDS-PAGE)
参考价格
9615.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

TFIIH is a multicomponent basal transcription factor complex. Nine subunits have been identified within the TFIIH holoenzyme complex. Various enzymatic activities, including DNA repair, helicase, and cyclin-dependent kinase activities, have been reported. The XPB, p62, p52, p44, and p34 subunits are thought to constitute the "core" of the TFIIH transcription machinery. Although the p44 and p34 subunits have no defined enzymatic activity, their zinc finger structures suggest that they may be DNA-binding proteins that might mediate interactions with soluble transcription factors. The cdk-activating kinase (CAK) subcomplex, comprising subunits Cdk7, cyclin H, amd MAT1, phosphorylate several cyclin-dependent kinases (cdks), as well as the carboxy-terminal domain of pol II. Several inherited human disorders such as Xeroderma pigmentosum (XP), Cockayne syndrome (CS) and trichothiodystrophy (TTD) are associated with mutations in TFIIH subunits.

外形

Clear and colorless frozen liquid solution

制备说明

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

基本信息

NACRESNA.26

产品性质

生物来源human
测定≥75% (SDS-PAGE)
形式frozen liquid
包装pkg of 2 μg
储存条件avoid repeated freeze/thaw cycles
浓度200 μg/mL
颜色clear colorless
UniProt登记号A8MX75
运输dry ice
储存温度−70℃
Gene Informationhuman ... ERCC2(2068)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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