产品说明
一般描述
Annexin VII (synexin) is a membrane binding protein that localizes in the nucleus and cytosol. In humans and mice, Annexin VII is encoded by a single gene that has alternatively spliced cassette exons. As a result, two isoforms of molecular mass of 47kDa and 51kDa are expressed. These isoforms differ in their N-terminal region and also have distinct tissue-specific expression patterns.
Anti-Annexin VII antibody, Mouse monoclonal (mouse IgG1 isotype) is derived from the 203-217/6 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant mouse Annexin VII. The human annexin VII (ANXA7) is located on chromosome 10q21.
特异性
Mouse monoclonal anti-annexin VII antibody reacts with human, bovine, rabbit, dog, rat, mouse, and chicken Annexin VII.
免疫原
recombinant mouse annexin VII.
应用
Anti-Annexin VII antibody, Mouse monoclonal has been used in:
- western blotting
- immunocytochemistry
- immunohistochemistry
生化/生理作用
Antibodies reacting specifically with Annexin VII serve as an essential tool for the detection of this molecule in various cells. The human annexin VII (ANXA7) possesses a tumor suppressor role in prostate cancer. Hence it can be used an important biomarker along with syndecan-1 to predict the survival rates in prostate cancer patients.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| MDL编号 | MFCD03792412 |
| NACRES | NA.44 |
产品性质
| 质量水平 | 200 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | 203-217/6, monoclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen 47-51 kDa |
| species reactivity | rabbit, rat, bovine, chicken, canine, mouse, human |
| technique(s) | immunocytochemistry: suitable using methanol or 1% paraformaldehyde/0.1% glutaraldehyde immunohistochemistry (frozen sections): suitable microarray: suitable western blot: 0.5-1 μg/mL using whole cell extract of culture mouse connective tissue (A9) cells. |
| 同位素/亚型 | IgG1 |
| UniProt登记号 | P20073 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... ANXA7(310) mouse ... Anxa7(11750) rat ... Anxa7(155423) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
