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Clarithromycin, Ready Made Solution

品牌
Sigma-Aldrich
CAS
81103-11-9
货号
SBR00011
规格纯度
50 mg/mL in DMSO
参考价格
2310.36 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.

应用

Clarithromycin may be used for-

  • the study of the effects of clarithromycin on rate-dependent changes in QT, Tp-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
  • the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
  • the study of the synergism of NAB741 with clarithromycin in microtiter plates.

生化/生理作用

Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.

包装

2ML

其他说明

Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids

基本信息

经验(实验)分子式C38H69NO13
分子量747.95
MDL编号MFCD00865140
PubChem化学物质编号329824644
NACRESNA.85

产品性质

质量水平200
描述Ready Made Solution
形式liquid
储存条件dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.)
浓度50 mg/mL in DMSO
颜色 colorless to faint yellow
作用机制protein synthesis | interferes
抗生素抗菌谱Gram-positive bacteria
储存温度−20℃
InChI1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1
InChI keyAGOYDEPGAOXOCK-KCBOHYOISA-N

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)188.6 °F
闪点(C)87 ℃

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