产品说明
一般描述
Clarithromycin is a macrolide antibiotic, which has both antibacterial and anti-inflammatory actions. It is a semi-synthetic 14-membered derivative of erythromycin A, which is resistant to degradation under acidic conditions.
应用
Clarithromycin may be used for-
- the study of the effects of clarithromycin on rate-dependent changes in QT, Tp-e and proarrhythmic events performed on arterially perfused rabbit left ventricular wedge preparations
- the culture of parasites expressing GFP (green fluorescence protein) targeted to the apicoplast, to be further used for microscopy-based assays
- the study of the synergism of NAB741 with clarithromycin in microtiter plates.
生化/生理作用
Macrolides, such as clarithromycin, prevent protein synthesis in bacteria, by binding to 50S ribosomal subunit. It also binds to other ribosomal proteins, and prevents the translocation of pepti-dyl-tRNA. In patients with refractory asthma, it is capable of regulating the levels of interleukin-8 (IL-8), and neutrophil accumulation and activation in lungs. Thus, it might be used as an additional therapy in asthma to reduce noneosinophilic airway inflammation.
包装
2ML
其他说明
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Combustible liquids
基本信息
| 经验(实验)分子式 | C38H69NO13 |
| 分子量 | 747.95 |
| MDL编号 | MFCD00865140 |
| PubChem化学物质编号 | 329824644 |
| NACRES | NA.85 |
产品性质
| 质量水平 | 200 |
| 描述 | Ready Made Solution |
| 形式 | liquid |
| 储存条件 | dry media (Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Combustible liquids.) |
| 浓度 | 50 mg/mL in DMSO |
| 颜色 | colorless to faint yellow |
| 作用机制 | protein synthesis | interferes |
| 抗生素抗菌谱 | Gram-positive bacteria |
| 储存温度 | −20℃ |
| InChI | 1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1 |
| InChI key | AGOYDEPGAOXOCK-KCBOHYOISA-N |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | 188.6 °F |
| 闪点(C) | 87 ℃ |
