产品说明
一般描述
The protein encoded by this gene is a member of the RAD51 protein family. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq) The RAD51 gene is located on human chromosome 15q15.1.
免疫原
RAD51 (NP_002866.2, 1 a.a. ~ 339 a.a) full-length human protein.
Sequence
MAMQMQLEANADTSVEEESFGPQPISRLEQCGINANDVKKLEEAGFHTVEAVAYAPKKELINIKGISEAKADKILAEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQGGIETGSITEMFGEFRTGKTQICHTLAVTCQLPIDRGGGEGKAMYIDTEGTFRPERLLAVAERYGLSGSDVLDNVAYARAFNTDHQTQLLYQASAMMVESRYALLIVDSATALYRTDYSGRGELSARQMHLARFLRMLLRLADEFGVAVVITNQVVAQVDGAAMFAADPKKPIGGNIIAHASTTRLYLRKGRGETRICKIYDSPCLPEAEAMFAINADGVGDAKD
应用
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Western Blotting (1 paper)
Anti-RAD51 antibody produced in mouse has been used in Western blot analysis and Immunohistochemistry.
生化/生理作用
RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein replication protein A (RPA) and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage.
RAD51 specifically repairs double stranded breaks in the DNA. Upregulation of RAD51 is observed in a number of tumors and indicates poor prognosis. Rad51 induces G0/G1 to S phase transition in cell cycle. Therefore, inhibition of RAD51 reduces the progression of cancer in cases such as cervical cancer.
外形
Solution in phosphate buffered saline, pH 7.4
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
基本信息
| NACRES | NA.41 |
产品性质
| 质量水平 | 100 |
| 生物来源 | mouse |
| 偶联物 | unconjugated |
| 抗体形式 | purified immunoglobulin |
| antibody product type | primary antibodies |
| 克隆 | polyclonal |
| 形式 | buffered aqueous solution |
| 分子量 | antigen ~37 kDa |
| species reactivity | rat, human, mouse |
| technique(s) | immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable western blot: 1 μg/mL |
| NCBI登记号 | NM_002875 |
| UniProt登记号 | Q06609 |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| Gene Information | human ... RAD51(5888) |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 1 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
