位置:首页 > 品牌 > Sigma-Aldrich >

Anti-phospho-α-B Crystallin (14-25) (pSer19) antibody produced in rabbit

品牌
Sigma-Aldrich
货号
C7740
规格纯度
affinity isolated antibody, lyophilized powder
参考价格
7212.68 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

特异性

Does not detect the unphosphorylated protein.

免疫原

synthetic phosphopeptide surrounding the region of human α-B crystallin that contains serine 19.

应用

Anti-phospho-α-B Crystallin (14-25) (pSer19) antibody produced in rabbit

  • Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 10μg/mL
  • Indirect immunofluorescence at a concentration of 5μg/mL
  • Western blotting at a concentration of 0.5μg/mL using human cell extract
  • It also used in 1- and 2-D immune blotting analysis.

生化/生理作用

α-Crystallin B chain is a protein encoded by the CRYAB gene in humans. αB-crystallin (ABC) and HSP27 are most abundant in human tissues. It is predominantly expressed in triple-negative breast cancer (TNBC) and leads to aggressive tumor phenotype. αB-crystallin expression is primary found in breast carcinomas and brain metastases. αB-crystallin is overexpressed or silenced in two different TNBC cell lines. It is a novel regulator of brain metastasis in TNBC and acts as a potential biomarker for drug target in aggressive disease. αB-crystallin and VEGF expressions in human conjunctival squamous cell carcinoma (CSCCs) may play an important role in the pathogenesis. Mutation in the gene is responsible for a number of inherited human disorders, which include cardiomyopathy, skeletal muscle myopathy and cataracts.

外形

Lyophilized from phosphate buffered saline, pH 7.4, containing 3% bovine serum albumin and 0.05% sodium azide.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD07370435
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
species reactivitymouse, rat, human, bovine
technique(s)immunohistochemistry (formalin-fixed, paraffin-embedded sections): 10 μg/mL
indirect immunofluorescence: 5 μg/mL
western blot: 0.5 μg/mL using human cell extract
UniProt登记号P02511
运输dry ice
储存温度−20℃
Gene Informationhuman ... CRYAB(1410)
mouse ... Cryab(12955)
rat ... Cryab(25420)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号