产品说明
应用
Interferon-αA human has been used to:
- study the effect of Chikungunya virus on interferon-mediated JAK (Janus kinase)-STAT (signal transducers and activators of transcription) signaling
- study the effect of interferon-α and PRK2 (protein kinase C-related kinase 2) inhibitors on hepatitis C virus replication
- compare the effect of Monascus pigment derivatives on hepatitis C virus replication
生化/生理作用
Cytokine with anti-viral, anti-proliferative, immunoregulatory, and proinflammatory activities. Type I Interferons are a closely related family of 165-172 amino acid proteins that are produced by leukocytes (α subtypes), fibroblasts (β subtypes), lymphocytes (ω subtypes) and ruminant embryos (τ subtypes). Interferon induces a variety of effects on target cells including antiviral, antiproliferative and immunomodulatory activities.
外形
Supplied as a solution in 5 mM sodium acetate, pH 4.0.
分析说明
The biological activity is determined in the cytopathic effect inhibition assay using MDBK cells with vesicular stomatitis virus (VSV). A cytopathic effect of 50% is produced with 1 unit/ml interferon. The units are determined with respect to WHO International standard reference for human interferonαA.
基本信息
| MDL编号 | MFCD01635115 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human |
| 重组 | expressed in E. coli |
| 测定 | ≥95% |
| 形式 | buffered aqueous solution |
| 分子量 | 19 kDa |
| 包装 | pkg of 20 μg |
| 浓度 | ≥0.2 mg/mL |
| technique(s) | cell culture | mammalian: suitable |
| 杂质 | endotoxin, tested |
| 颜色 | colorless |
| UniProt登记号 | P01563 |
| 运输 | wet ice |
| 储存温度 | −20℃ |
| Gene Information | human ... IFNA2(3440) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves |
