产品说明

一般描述

The calcium sensing receptor (CASR) gene with 11 exons is mapped to human chromosome 3q13.33-q21.1. CASR is a member of the C family of G protein–coupled receptors and is mainly localized in the parathyroid gland and the thick ascending limb of the Henle loop. CASR is a 1078 amino acid protein.

免疫原

peptide corresponding to amino-acids 15-29 at the extracellular N-terminus of calcium sensing receptor.

应用

Monoclonal anti-calcium sensing receptor antibody produced in mouse has been used in western blotting and immunohistochemistry.
Monoclonal Anti-Calcium Sensing Receptor antibody produced in mouse is suitable for the following applications:

• Indirect ELISA
• Immunoblotting
• Immunocytochemistry
• Immunohistochemistry (formalin-fixed, paraffin-embedded sections)
• Western blotting at a concentration of 3-6μg/mL using total extract from rat kidney

生化/生理作用

Calcium sensing receptor (CASR) regulates cell activity according to the extracellular calcium concentration. It also plays a major role in controlling parathyroid hormone (PTH) secretion. Thus, this protein can be considered as a potent target for therapeutic agents designed to modify parathyroid gland function. CASR has a role in key signal transduction pathways in several tissues such as parathyroid gland, kidney, gastrointestinal tract, placenta, pancreas and brain. Mutation in the gene is associated with autosomal dominant hypocalcemic, hypercalciuria and Bartter syndrome.

外形

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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