Anti-ALKBH1 Antibody

产品说明

一般描述

ALKBH1 is a DNA lyase that is critical for DNA repair and specifically repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. ALKBH1 can also cleave both single-stranded and double-stranded DNA at basic sites, and ALKBH1 can induce double stranded breaks at basic sites. Finally, ALKBH1 plays a role in placental trophoblast lineage differentiation during development, and ALKBH1 may also play a role in neuronal development and migration. ALKBH1 is widely expressed and localizes to mitochondria and nucleus. The nuclear localization of ALKBH1 appears to be as part of fusion proteins with nuclear targeted proteins or when the first 26 N-terminal residues are removed.

特异性

Human AlkB homolog 1 is a mitochondrial protein that demethylates 3-methylcytosine in DNA and RNA (Westbye, M.P., et al. (2008). JBC. 283:25046-25056).

免疫原

KLH-conjugated linear peptide corresponding to the substrate binding region of human ALKBH1.
Epitope: Around the Substrate binding region

应用

Research Sub Category
Nuclear Receptors
Immunohistochemistry Analysis: A 1:50-250 dilution from a representative lot detected ALKBH1 in human pancreas and human kidney tissue.
Anti-ALKBH1 Antibody is an antibody against ALKBH1 for use in Immunohistochemistry and Immunocytochemistry.
Research Category
Epigenetics & Nuclear Function

质量

Evaluated by Western Blotting in human skeletal muscle tissue lysate.
Western Blotting Analysis: 0.1 µg/mL of this antibody detected ALKBH1 in 10 µg of human skeletal muscle tissue lysate.

目标描述

~45 kDa observed

外形

Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Affinity purified

储存及稳定性

Stable for 1 year at 2-8°C from date of receipt.

其他说明

Concentration: Please refer to lot specific datasheet.

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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