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Leupeptin trifluoroacetate salt

亮肽素 三氟乙酸盐

品牌
Sigma-Aldrich
CAS
147385-61-3
货号
L2023
规格纯度
≥90% (HPLC), microbial
参考价格
370.26 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

5, 10, 25, 50, 100 mg in glass bottle

生化/生理作用

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

分析说明

由于三种形式在溶液中达到平衡,亮抑酶肽可在 HPLC 上形成多个峰。通过三个主峰测定纯度。主要的杂质肽为外消旋亮抑酶肽。

基本信息

经验(实验)分子式C20H38N6O4 · xC2HF3O2
分子量426.55 (free base basis)
MDL编号MFCD00133458
PubChem化学物质编号329817397
NACRESNA.77

产品性质

质量水平200
生物来源microbial
测定≥90% (HPLC)
形式powder
溶解性H2O: 10 mM (Solutions are stable only a few hours. Stock solutions are stable up to 6 months at −20 ℃.)
储存温度−20℃
SMILES stringOC(=O)C(F)(F)F.CC(C)C[C@H](NC(C)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C=O
InChI1S/C20H38N6O4.C2HF3O2/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;3-2(4,5)1(6)7/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);(H,6,7)/t15-,16-,17-;/m0./s1
InChI keyWUHGBZVQELGOMH-FRKSIBALSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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