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5,5-Diphenylhydantoin Sodium Salt

苯妥英

品牌
Sigma-Aldrich
CAS
630-93-3
货号
D4505
规格纯度
≥99%
参考价格
787.89 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

5,5-Diphenylhydantoin sodium salt is a derivative of phenytoin. 5,5-Diphenylhydantoin is used for treating epilepsy and has antiepileptic activity. It functions by blocking the sodium channels and modulates excitation of neurons. However, the side effects include hypertrichosis and overgrowth of gum tissue around the teeth. It promotes proliferation of the neural stem cells by modulating growth factors. Diphenylhydantoin is toxic and induces apoptosis in cultured cerebellar granule neurons.

应用

5,5-Diphenylhydantoin sodium salt has been used:

  • in the cream preparation for treating burn wounds
  • in seizure behavior testing as an anticonvulsant in Drosophila
  • in in vivo embryo toxicity test in mouse embryonic stem cells

生化/生理作用

减少癫痫大发作的发生率;可能通过 Na+、K+ 和 Ca2+ 通道的影响而稳定可兴奋膜。

特点和优势

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

基本信息

线性分子式C15H11N2O2Na
分子量274.25
EC 号211-148-2
MDL编号MFCD00069674
PubChem化学物质编号24277707
NACRESNA.77

产品性质

质量水平200
测定≥99%
溶解性aqueous base: soluble
SMILES string[Na]N1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI1S/C15H12N2O2.Na/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12;/h1-10H,(H2,16,17,18,19);/q;+1/p-1
InChI keyFJPYVLNWWICYDW-UHFFFAOYSA-M
Gene Informationhuman ... CNR1(1268), CNR2(1269), CYP2C9(1559), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Faah(29347), Scn1a(81574), Scnn1g(24768), Slc6a1(79212)

安全信息

象形图GHS07GHS08
警示用语:Warning
危险声明H302 - H317 - H361
预防措施声明P201 - P202 - P280 - P301 + P312 - P302 + P352 - P308 + P313
危险分类Acute Tox. 4 Oral - Repr. 2 - Skin Sens. 1
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges

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