产品介绍：
产品说明
一般描述
Cytosine 5′-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac) is a sugar-nucleotide produced by CMP-Neu5Ac synthetase from CTP and Neu5Ac.
应用
Cytidine-5′-monophospho-N-acetylneuraminic acid sodium salt has been used:
- as a standard in high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC-PAD) for nucleotide sugar analysis in Joubert syndrome type 10 (JBTS10) patient cells and control skin fibroblasts,
- As a substrate for the enzymatic sialylation of G2 glycoforms, resialylation assay,
- in in-vitro sialyltransferase assay
包装
25 mg in poly bottle
1, 5 mg in glass bottle
生化/生理作用
Cytosine 5′-monophosphate N-acetylneuraminic acid (CMP-Neu5Ac) is used as a substrate for Golgi sialyltransferases to form sialic acid and its conjugates.
胞苷-5′-单磷酸酯-N-乙酰基神经氨酸(CMP-唾液酸)是唾液酸转移酶的底物。主要用于多糖的酶促唾液酸化。
制备说明
通过Schauer, R.等人Hoppe Seyler′s Z. Physiol. Chem., 353, 883 (1972)的方法酶促制备。
CMP-NAN是非常酸不稳定的。
基本信息
| 线性分子式 | C20H31N4O16P |
| 分子量 | 636.43 |
| Beilstein | 4224251 |
| MDL编号 | MFCD00151579 |
| PubChem化学物质编号 | 24893038 |
| NACRES | NA.51 |
产品性质
| 质量水平 | 200 |
| 测定 | ≥85% (HPLC) |
| 储存温度 | −20℃ |
| SMILES string | [Na+].CC(=O)N[C@@H]1[C@@H](O)C[C@@](O[C@@H]1[C@H](O)[C@H](O)CO)(OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(N)=NC3=O)C(O)=O |
| InChI | 1S/C20H31N4O16P.Na/c1-7(26)22-12-8(27)4-20(18(32)33,39-16(12)13(29)9(28)5-25)40-41(35,36)37-6-10-14(30)15(31)17(38-10)24-3-2-11(21)23-19(24)34;/h2-3,8-10,12-17,25,27-31H,4-6H2,1H3,(H,22,26)(H,32,33)(H,35,36)(H2,21,23,34);/q;+1/p-1/t8-,9+,10+,12+,13+,14+,15+,16?,17+,20+;/m0./s1 |
| InChI key | VFRHSOGUONIUOR-CTFMUGKASA-M |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
