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2′-Deoxyuridine 5′-monophosphate disodium salt

2′-Deoxyuridine 5′-monophosphate disodium salt

品牌
Sigma-Aldrich
CAS
42155-08-8
货号
D3876
规格纯度
Sigma Grade
参考价格
2884.53 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) is a substrate for thymidylate synthase and is converted to deoxythymidine monophosphate (dTMP).

应用

2′-Deoxyuridine 5′-monophosphate (dUMP) is used by the enzyme thymidylate synthetase (TS) (EC 2.1.1.45) for the de novo production of dTMP. dUMP is used as the reference substrate in studies of dUMP analogues in potential chemotherapy applications.
2′-Deoxyuridine 5′-monophosphate disodium salt has been used:

  • in ultraperformance liquid chromatography-tandem mass spectrometry (UPLC/MS/MS) assay
  • to stimulate proliferation of peripheral blood mononuclear cell (PBMCs) exposed to influenza virus antigen
  • in thymidylate synthase activity assay Helicobacter pylori

包装

100, 250 mg in poly bottle
1 g in poly bottle

生化/生理作用

2′-Deoxyuridine 5′-monophosphate disodium salt (dUMP) conversion to pyrimidine is inhibited by methotrexate. The inhibition of dUMP to deoxythymidine monophosphate (dTMP) at the methylation step is a key in controlling bacterial and eukaryotic cell growth.

基本信息

线性分子式C9H11N2O8PNa2
分子量352.15
EC 号255-687-1
MDL编号MFCD00065282
PubChem化学物质编号24893787
NACRESNA.51

产品性质

质量水平200
等级Sigma Grade
储存温度−20℃
SMILES string[Na].OC1CC(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
InChI1S/C9H13N2O8P.Na.H/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17;;/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17);;
InChI keyWXIVKKBDJOCRNB-UHFFFAOYSA-N

安全信息

象形图GHS07
警示用语:Warning
危险声明H302 - H315 - H319 - H335
预防措施声明P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338
危险分类Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码11 - Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备dust mask type N95 (US), Eyeshields, Gloves

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