产品说明
一般描述
Chemical structure: peptide
应用
Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.
包装
5 mL in glass bottle
生化/生理作用
Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.
K+选择性离子载体环羧酚酸肽；钾离子载体，其可解偶联氧化磷酸化、诱导鼠胸腺细胞凋亡、抑制NGF诱导的神经元分化、并拮抗ET诱导的血管收缩。
其他说明
Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.
基本信息
| 经验(实验)分子式 | C54H90N6O18 |
| 分子量 | 1111.32 |
| Beilstein | 78657 |
| MDL编号 | MFCD00005114 |
| PubChem化学物质编号 | 24900743 |
产品性质
| 质量水平 | 200 |
| 生物来源 | Streptomyces sp. |
| 测定 | ≥90% (HPLC) |
| 形式 | liquid |
| 储存条件 | (Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.) |
| 浓度 | ~1 mg/mL in DMSO |
| 颜色 | colorless |
| 作用机制 | cell membrane | interferes |
| 抗生素抗菌谱 | Gram-positive bacteria parasites viruses |
| 运输 | wet ice |
| 储存温度 | 2-8℃ |
| SMILES string | CC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C |
| InChI | 1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1 |
| InChI key | FCFNRCROJUBPLU-RPUZOQEISA-N |
安全信息
| 储存分类代码 | 10 - Combustible liquids |
| WGK | WGK 1 |
| 闪点(F) | 188.6 °F - closed cup |
| 闪点(C) | 87 ℃ - closed cup |
| 个人防护装备 | Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter |
