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Valinomycin

缬氨霉素

品牌
Sigma-Aldrich
CAS
2001-95-8
货号
V3639
规格纯度
Ready Made Solution, ~1 mg/mL in DMSO
参考价格
798.75 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Chemical structure: peptide

应用

Valinomycin is a cyclic dodecadepsipeptides with potassium ionophoric properties. It is used to study ion transport in biological systems. It is used to study its inhibitory effect on intact cells and the growth of bacteria and yeast. It is used to induce apoptosis.

包装

5 mL in glass bottle

生化/生理作用

Valinomycin is a K+-selective ionophoric cyclodepsipeptide. It is a potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and antagonizes ET-induced vasoconstriction. It is reported to be insecticidal, nematicidal and antiviral.
K+选择性离子载体环羧酚酸肽;钾离子载体,其可解偶联氧化磷酸化、诱导鼠胸腺细胞凋亡、抑制NGF诱导的神经元分化、并拮抗ET诱导的血管收缩。

其他说明

Keep container tightly closed in a dry and well-ventilated place. Hygroscopic.

基本信息

经验(实验)分子式C54H90N6O18
分子量1111.32
Beilstein78657
MDL编号MFCD00005114
PubChem化学物质编号24900743

产品性质

质量水平200
生物来源Streptomyces sp.
测定≥90% (HPLC)
形式liquid
储存条件 (Keep container tightly closed in a dry and well-ventilated place. Hydroscopic.)
浓度~1 mg/mL in DMSO
颜色 colorless
作用机制cell membrane | interferes
抗生素抗菌谱Gram-positive bacteria
parasites
viruses
运输wet ice
储存温度2-8℃
SMILES stringCC(C)[C@@H]1NC(=O)[C@H](C)OC(=O)[C@@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC(=O)[C@@H](NC(=O)[C@H](C)OC(=O)[C@H](NC(=O)[C@H](OC1=O)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C)C(C)C
InChI1S/C54H90N6O18/c1-22(2)34-49(67)73-31(19)43(61)55-38(26(9)10)53(71)77-41(29(15)16)47(65)59-36(24(5)6)51(69)75-33(21)45(63)57-39(27(11)12)54(72)78-42(30(17)18)48(66)60-35(23(3)4)50(68)74-32(20)44(62)56-37(25(7)8)52(70)76-40(28(13)14)46(64)58-34/h22-42H,1-21H3,(H,55,61)(H,56,62)(H,57,63)(H,58,64)(H,59,65)(H,60,66)/t31-,32-,33-,34-,35+,36+,37-,38-,39-,40+,41+,42+/m0/s1
InChI keyFCFNRCROJUBPLU-RPUZOQEISA-N

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)188.6 °F - closed cup
闪点(C)87 ℃ - closed cup
个人防护装备Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

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