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Sushi Peptide S3

品牌
Sigma-Aldrich
货号
SRP6562
规格纯度
recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
参考价格
1944.65 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

TheSushi Peptide S3 is a trimer of one of the high endotoxin-binding domains, Sushi 3 (or S3) within Factor C, a lipopolysaccharide (LPS)-sensitive serine protease of the horseshoe crab (Limulus Polyphemus). S3 display detergent-like properties in disrupting LPS aggregates, with specificity for palmitoyl-oleoyl-phosphatidylglycerol (POPG) resulting from electrostatic and hydrophobic forces between the peptides and the bacterial lipids. During interaction with POPG, the S3 resumes a mixture of α-helix and β-sheet structures. The unsaturated nature of POPG confers fluidity and enhances insertion of the peptides into the lipid bilayer, causing maximal disruption of the bacterial membrane. In short, peptide S3 can bind to lipopolysaccharide (LPS) and inhibit the growth of Gram-negative bacteria without affecting mammalian cells. It has been shown that endotoxin activates Factor C-based catalytic coagulation cascade resulting in the gelation of Limulus blood. This process is the basis of Limulus Amebocyte Lysate (LAL) endotoxin detection method.

外形

Lyophilized from 50 mM Tris. HCl and 100 mM NaCl (pH 8.0).

重悬

Reconstitute with water. Recommended conc: 0.1 - 1 mg/mL.

基本信息

NACRESNA.32

产品性质

重组expressed in E. coli
测定≥90% (SDS-PAGE)
形式lyophilized powder
分子量 16.1 kDa
包装pkg of 1 mg
pkg of 100 μg
pkg of 20 μg
运输wet ice
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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