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BRD3(306-417) his tag

品牌
Sigma-Aldrich
货号
SRP6280
规格纯度
recombinant, expressed in E. coli, ≥98% (SDS-PAGE)
参考价格
3896.85 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BRD3 binds hyper-acetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. It regulates transcription by promoting the binding of the transcription factor GATA1 to its targets and transcription of the CCND1 gene. A chromosomal aberration involving BRD3 was found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. The recombinant protein includes Bromodomain-containing protein 3 (contains 306-417 aa) with N-terminal His-tag.

外形

rh-BRD3-BD2 is supplied as a solution in PBS Buffer containing 10% glycerol.

基本信息

NACRESNA.32

产品性质

重组expressed in E. coli
测定≥98% (SDS-PAGE)
形式liquid
分子量 15.5 kDa
包装pkg of 1 mg
pkg of 100 μg
pkg of 20 μg
浓度2 mg/mL
NCBI登记号NM_007371
UniProt登记号Q15059
运输dry ice
储存温度−70℃
Gene Informationhuman ... BRD3(8019)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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