产品介绍:
产品说明
应用
1,4-Naphthoquinone is the key structural moiety of many anticancer and antifungal agents.
It can be used to synthesize:
- 3,3-Disubstituted oxindoles via asymmetric Michael addition to oxindole.
- Bioactive isoindolines via asymmetric 1,3-dipolar cycloaddition to azomethine ylides generated in situ from aldehydes and diethyl aminomalonate.
- α,α-Difluoro-β-hydroxy ketone via ‘on water′ catalyst-free Mukaiyama-aldol reaction with difluoroenoxysilane.
- 2-Hydroxy-3-anilino-1,4-naphthoquinone, which shows potent in vivo antimalarial activity.
Additional appilcation include:
- As an arylation reagent for the α-arylation of aldehydes.
- As a starting material in the multi-step synthesis of benz[f]indole-4,9-diones.
基本信息
经验(实验)分子式 | C10H6O2 |
分子量 | 158.15 |
Beilstein | 878524 |
EC 号 | 204-977-6 |
MDL编号 | MFCD00001676 |
PubChem化学物质编号 | 329762061 |
NACRES | NA.22 |
产品性质
质量水平 | 200 |
等级 | purum |
测定 | ≥96.5% (HPLC) |
形式 | powder |
mp | 119-122 ℃ (lit.) 120-124 ℃ |
SMILES string | O=C1C=CC(=O)c2ccccc12 |
InChI | 1S/C10H6O2/c11-9-5-6-10(12)8-4-2-1-3-7(8)9/h1-6H |
InChI key | FRASJONUBLZVQX-UHFFFAOYSA-N |
安全信息
象形图 | |
警示用语: | Danger |
危险声明 | H301 + H311 - H314 - H317 - H330 - H335 - H410 |
预防措施声明 | P260 - P280 - P301 + P310 + P330 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 |
危险分类 | Acute Tox. 1 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Corr. 1C - Skin Sens. 1 - STOT SE 3 |
靶器官 | Respiratory system |
储存分类代码 | 6.1B - Non-combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials |
WGK | WGK 3 |
闪点(F) | 285.8 °F |
闪点(C) | 141 ℃ |
个人防护装备 | Eyeshields, Faceshields, Gloves, type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges |