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Isotretinoin

异维A酸

CAS
4759-48-2
货号
I0800000
规格纯度
European Pharmacopoeia (EP) Reference Standard
参考价格
1277.32 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.
Isotretinoin, a vital isomer of vitamin A, is implicated in the treatment of severe recalcitrant nodular acne disorder. It is the only drug known to operate against the major pathogenic factors of acne. It serves to diminish the sebaceous gland activity, thereby resulting in the correction of keratinization defect.

应用

Isotretinoin may be used as an analytical reference standard for the determination of the analyte in pharmaceutical formulations by various chromatography techniques.

生化/生理作用

13--维甲酸 (RA) 具有抗炎和抗肿瘤操作。RA 的操作是通过 RAR-β 介导的和 RAR-α受体。RA 可减弱细胞因子刺激的小鼠系膜细胞 iNOS 的表达和活性。它诱导线粒体膜通透性转换,观察为肿胀和膜电位降低,并通过细胞凋亡途径刺激细胞色素 c 的释放牵连机制。这些活动被 EGTA 和环孢霉素 A 逆转。RA 也部分通过增加转录增加 MMP-1 蛋白表达。

包装

Unit quantity: 20 mg. Subject to change. The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

注意

Please find SDS provided by EDQM here..

其他说明

Sales restrictions may apply.

基本信息

经验(实验)分子式C20H28O2
分子量300.44
MDL编号MFCD00079542
PubChem化学物质编号329815327
NACRESNA.24

产品性质

生物来源synthetic
等级pharmaceutical primary standard
agencyEP
形式solid
manufacturer/tradenameEDQM
technique(s)gas chromatography (GC): suitable
liquid chromatography (LC): suitable
mp172-175 ℃ (lit.)
application(s)pharmaceutical (small molecule)
格式neat
SMILES string[H]\C(C(O)=O)=C(C)\C=C\C=C(C)\C=C\C1=C(C)CCCC1(C)C
InChI1S/C20H28O2/c1-15(8-6-9-16(2)14-19(21)22)11-12-18-17(3)10-7-13-20(18,4)5/h6,8-9,11-12,14H,7,10,13H2,1-5H3,(H,21,22)/b9-6+,12-11+,15-8+,16-14-
InChI keySHGAZHPCJJPHSC-XFYACQKRSA-N
Gene Informationhuman ... RARA(5914), RARB(5915), RARG(5916)

安全信息

象形图GHS07GHS08
警示用语:Danger
危险声明H315 - H319 - H335 - H360
预防措施声明P201 - P302 + P352 - P305 + P351 + P338 - P308 + P313
危险分类Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3
靶器官Respiratory system
储存分类代码6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGKWGK 3

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