产品说明
一般描述
A synthetic salen-manganese complex with high superoxide dismutase (SOD), catalase, and oxyradical scavenger activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation and imparts protection against Aβ40 and Aβ42 toxicity in hippocampal cultures.
A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation. Imparts protection against Aβ40 and Aβ42 toxicity in hippocampal cultures.
包装
10 mg in Plastic ampoule
Packaged under inert gas
生化/生理作用
Product does not compete with ATP.
Reversible: no
Primary Target
Superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities
Cell permeable: no
警告
Toxicity: Standard Handling (A)
重悬
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.
其他说明
Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol.130, 359.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.
法律信息
Not available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 经验(实验)分子式 | C16H14ClMnN2O2 |
| 分子量 | 356.69 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥90% (elemental analysis) |
| 形式 | solid |
| manufacturer/tradename | Calbiochem® |
| 储存条件 | OK to freeze protect from light |
| 颜色 | dark brown |
| 溶解性 | DMSO: 20 mg/mL |
| 运输 | ambient |
| 储存温度 | 2-8℃ |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 2 |
