产品说明
一般描述
Vaccination is well-accepted as an effective method to prevent infections by mounting pathogen-specific immune responses prior to the infection. Usually, immunization with vaccine antigens alone is not able to induce robust or long-lasting immune responses — resulting in failure of protective immunity against infections. Thus, adjuvants are required to enhance cellular or humoral immune responses upon immunization. Because vaccine adjuvants using Lipid A have proven to be safe and effective in inducing Th-1 type immune responses to heterologous proteins in animal and human vaccines, Avanti developed Phosphorylated HexaAcyl Disaccharide (PHAD®), the first fully synthetic monophosphoryl Lipid A available for use as an adjuvant in human vaccines.
应用
3D-PHAD® has been used:
- as a synthetic adjuvant for respiratory syncytial virus (RSV) vaccine
- as a synthetic adjuvant to prepare hepatitis B virus (HBV) and virus-like particles (VLP)-based human papillomavirus (HPV) vaccines
- in liposome preparation for the generation of army liposome formulation (ALF) for human immunodeficiency (HIV) gp140 antigen immunization studies in mice.
生化/生理作用
3-deacyl-phosphorylated hexa-acyl disaccharide (3D-PHAD®) is derived from monophosphoryl lipid A. It is amphiphilic and associates with the virosomal membranes.
包装
2 mL Amber Glass Crimp Cap Vial (699852P-1mg)
2 mL Amber Glass Crimp Cap Vial (699852P-5mg)
其他说明
For R&D use only. Not for drug, household, or other uses.
法律信息
3D-PHAD is a registered trademark of Avanti Polar Lipids, Inc.
PHAD is a registered trademark of Avanti Polar Lipids, Inc.
基本信息
| 经验(实验)分子式 | C82H158N3O20P |
| 分子量 | 1537.11 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (HPLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 1 mg (699852P-1mg) pkg of 1 × 5 mg (699852P-5mg) |
| manufacturer/tradename | Avanti Polar Lipids 699852P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1OC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+] |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
