产品说明
包装
1, 5 mg in glass bottle
生化/生理作用
CHIC-35 is cell-permeable, metabolically stable, and very potent inhibitor of SIRT1; IC50 of S-isomer is 60 nM; IC50 of mixed isomers is 124 nM. There is no inhibition of SIRT3 or HDAC. The IC50 for SIRT2 is 2.77 μM. Sirtuins are protein deacetylases, which represent a new class of histone deacetylases (HDAC) involved in gene silencing. SIRT modulators are potential therapeutics for cancer, diabetes, muscle differentiation, heart failure, neurodegeneration, and aging.
特点和优势
This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
基本信息
| 经验(实验)分子式 | C14H15ClN2O |
| 分子量 | 262.73 |
| MDL编号 | MFCD11045286 |
| PubChem化学物质编号 | 329775186 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 100 |
| 测定 | ≥97% (chiral, HPLC) |
| 形式 | solid |
| 溶解性 | DMSO: >10 mg/mL H2O: <2 mg/mL |
| 储存温度 | 2-8℃ |
| SMILES string | ClC1=CC=C(NC2=C3CCCC[C@@H]2C(N)=O)C3=C1 |
| InChI | 1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1 |
| InChI key | ABIVOOWWGYJNLV-JTQLQIEISA-N |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Faceshields, Gloves |
