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Tyr-Ile-Gly-Ser-Arg

品牌
Sigma-Aldrich
CAS
110590-64-2
货号
T7154
规格纯度
≥97% (HPLC)
参考价格
1558.27 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

Amino Acid Sequence

Tyr-Ile-Gly-Ser-Arg

应用

Tyr-Ile-Gly-Ser-Arg (YIGSR) can be used at the interface between the conjugated polymer and the tissue for the engineering of tissue interface. The product can also be used to study the role of integrins β1, α6, and α3 in promoting type II epithelial differentiation during lung maturation in the fetus.

生化/生理作用

Tyr-Ile-Gly-Ser-Arg (YIGSR) is a pentapeptide of the protein laminin that reduces the lung colony formation in mice administered with melanoma cells as well as can block the invasiveness of the cells in vitro. It inhibits the increased expression of endothelial nitric-oxide synthase in primary porcine aortic endothelial cells.
Tyr-Ile-Gly-Ser-Arg is a fragment of domain III of the laminin B1 chain . It is a major receptor binding site in laminin. It competes with laminin for the cell surface receptor. It is an inhibitor of tumor growth and metastasis.

制备说明

Tyr-Ile-Gly-Ser-Arg dissolves in water at 1 mg/ml to yield a clear, colorless solution.

基本信息

经验(实验)分子式C26H42N8O8
分子量594.66
MDL编号MFCD00076472
PubChem化学物质编号24900419
NACRESNA.32

产品性质

质量水平200
生物来源synthetic (organic)
测定≥97% (HPLC)
形式powder
technique(s)cell culture | mammalian: suitable
溶解性H2O: soluble 1 mg/mL, clear, colorless
储存温度−20℃
SMILES stringCC[C@H](C)[C@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O
InChI1S/C26H42N8O8/c1-3-14(2)21(34-22(38)17(27)11-15-6-8-16(36)9-7-15)24(40)31-12-20(37)32-19(13-35)23(39)33-18(25(41)42)5-4-10-30-26(28)29/h6-9,14,17-19,21,35-36H,3-5,10-13,27H2,1-2H3,(H,31,40)(H,32,37)(H,33,39)(H,34,38)(H,41,42)(H4,28,29,30)/t14-,17-,18-,19-,21-/m0/s1
InChI keyMWOGMBZGFFZBMK-LJZWMIMPSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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