产品介绍：
产品说明
应用
Bisindolylmaleimide X hydrochloride has been used as a protein kinase C (PKC) inhibitor:
- in chemotaxis assays
- to inhibit protein kinase C and to study its effects on the expression of EGR1, NAB2, ZEBRA, and Rta
- in the culture to study its effects on the expression of the kinase-insert domain-containing receptor (KDR)-B1, protein kinase Cθ (PKCθ)-M1a or Abl-HTa and on cell yield in baculovirus (BV)-infected insect cells
生化/生理作用
Bisindolylmaleimide X hydrochloride/Ro 31-8425, a strong and selective protein kinase C (PKC) inhibitor, can reduce the superoxide burst caused by various agonists in neutrophils. It can suppress the responses induced by cell surface receptors and phorbol esters in T cells. In humans, Ro 31-8425 can prevent neutrophil PKC in vitro with an IC50 of 5nM.
基本信息
| 经验(实验)分子式 | C26H24N4O2 · HCl |
| 分子量 | 460.96 |
| MDL编号 | MFCD04972010 |
| PubChem化学物质编号 | 329773224 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 生物来源 | synthetic (organic) |
| 测定 | ≥90% |
| 形式 | solid |
| 溶解性 | DMSO: soluble |
| 储存温度 | −20℃ |
| SMILES string | Cl.Cn1cc(C2=C(C(=O)NC2=O)c3c4CC(CN)CCn4c5ccccc35)c6ccccc16 |
| InChI | 1S/C26H24N4O2.ClH/c1-29-14-18(16-6-2-4-8-19(16)29)23-24(26(32)28-25(23)31)22-17-7-3-5-9-20(17)30-11-10-15(13-27)12-21(22)30;/h2-9,14-15H,10-13,27H2,1H3,(H,28,31,32);1H |
| InChI key | IMBOYWXMTUUYGZ-UHFFFAOYSA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
