位置:首页 > 品牌 > Sigma-Aldrich >

β-Secretase Inhibitor II-CAS 263563-09-3-Calbiochem

品牌
Sigma-Aldrich
CAS
263563-09-3
货号
565749
规格纯度
The β-Secretase Inhibitor II, also referenced under CAS 263563-09-3, controls the biological activity of β-Secretase. This small molecule/inhibitor is primarily used for Neuroscience applications.
参考价格
1203.36 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A potent, cell-permeable, and reversible inhibitor of β-secretase that corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stably transfected with wild-type APP751.
A potent, cell-permeable, and reversible inhibitor of β-secretase. Corresponds to the β-secretase cleavage site (VNL-DA) of the Swedish mutant Amyloid Precursor Protein (APP). Inhibits the formation of both Aβtotal (IC50 = 700 nM) and Aβ1-42 (IC50 = 2.5 µM) in Chinese hamster ovary (CHO) cells stable transfected with wild-type APP751.

包装

1, 5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Target IC50: 700 nM and 2.5 µM against Aβtotal and Aβ1-42, respectively
Product does not compete with ATP.
Reversible: yes
Cell permeable: yes
Primary Target
β-secretase

警告

Toxicity: Standard Handling (A)

序列

Z-Val-Leu-Leu-CHO

重悬

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

其他说明

Abbenante, G., et al. 2000. Biochem. Biophys. Res. Commun. 268, 133.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C25H39N3O5
分子量461.59

产品性质

质量水平100
测定≥95% (HPLC)
形式solid
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
protect from light
颜色 white
溶解性DMSO: 5 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号