产品介绍：
产品说明
一般描述
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) is an activator of carboxyl group commonly used in peptide synthesis. It also participates in the carboxylic acid esterification. It shows characteristics similar to benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate (BOP) and can be utilized as an alternative to BOP in peptide bond formation.
应用
(Benzotriazol-1-yloxy)tripyrrolidinophosphonium hexafluorophosphate (PyBOP) may be used in the following studies:
- As coupling reagent in the preparation strategies for peptide-oligonucleotide conjugates.
- Synthesis of structured pure triacylglycerol (TAG) regioisomers.
- As coupling reagent in the synthesis of a 3,5-pyrazolidinedione on soluble polyethylene glycol (PEG) polymer support.
- Synthesis of herceptin- nanoparticles.
BOP 偶联剂类似物，不产生致癌副产物 HMPA。
法律信息
PyBOP is a registered trademark of Merck KGaA, Darmstadt, Germany
基本信息
| 线性分子式 | C18H28N6OP · PF6 |
| 分子量 | 520.39 |
| Beilstein | 3584612 |
| MDL编号 | MFCD00077411 |
| PubChem化学物质编号 | 329749882 |
| NACRES | NA.22 |
产品性质
| 质量水平 | 200 |
| 等级 | purum |
| 测定 | ≥97.0% (TLC) |
| reaction suitability | reaction type: Coupling Reactions |
| mp | ~150 ℃ 154-156 ℃ (dec.) (lit.) |
| application(s) | peptide synthesis |
| 储存温度 | 2-8℃ |
| SMILES string | F[P-](F)(F)(F)(F)F.C1CCN(C1)[P+](On2nnc3ccccc23)(N4CCCC4)N5CCCC5 |
| InChI | 1S/C18H28N6OP.F6P/c1-2-10-18-17(9-1)19-20-24(18)25-26(21-11-3-4-12-21,22-13-5-6-14-22)23-15-7-8-16-23;1-7(2,3,4,5)6/h1-2,9-10H,3-8,11-16H2;/q+1;-1 |
| InChI key | VIAFLMPQBHAMLI-UHFFFAOYSA-N |
安全信息
| 象形图 |   |
| 警示用语： | Warning |
| 危险声明 | H302 - H317 - H410 |
| 预防措施声明 | P261 - P264 - P273 - P280 - P301 + P312 - P302 + P352 |
| 危险分类 | Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Skin Sens. 1 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
