位置:首页 > 品牌 > Sigma-Aldrich >

Phosphoglucomutase 1 human

品牌
Sigma-Aldrich
货号
SAE0022
规格纯度
lyophilized powder, recombinant, expressed in E. coli
参考价格
4588.16 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Phosphoglucomutase-1 (PGM1) is an evolutionarily conserved enzyme that belongs to the phosphohexose mutase family. It is the major isoform of PGM in skeletal muscle and most other tissues. The PGM1 gene is mapped to human chromosome 1p31.3.

生化/生理作用

Phosphoglucomutase-1 (PGM1) catalyzes the bidirectional interconversion of glucose-1-phosphate (G-1-P) and glucose-6-phosphate (G-6-P). It regulates carbohydrate metabolism, energy production, and protein N-glycosylation. PGM1 participates in the biosynthesis of nucleotide sugars required for glycan biosynthesis. Variation in the PGM1 gene leads to PGM1 deficiency, which is considered an inherited metabolic disorder in humans. PGM1 deficiency causes autosomal recessive diseases such as glycogen storage disease type XIV and congenital disorder of protein N-glycosylation. Affected patients show multiple disease phenotypes, reflecting the central role of the enzyme in glucose homeostasis. The influence of PGM1 deficiency on protein glycosylation patterns is also widespread. PGM1 acts as a metabolic tumor suppressor.

单位定义

One unit will convert 1.0 μmole of α-D-Glucose-1-Phosphate to α-D-Glucose-6-phosphate per minute at pH 7.4 at 30 ℃.

外形

Supplied as a lyophilized powder containing tris-buffered saline, EDTA, DTT and stabilizer.

基本信息

酶学委员会(EC)编号5.4.2.2 ( BRENDA | IUBMB )
NACRESNA.54

产品性质

质量水平200
重组expressed in E. coli
描述PGM1 isoform sequence with a predicted molecular mass of 61.3kDa.
测定≥95% (PAGE)
形式lyophilized powder
specific activity≥400 units/mg protein
运输dry ice
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 2
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

推荐产品
| 首页 | 联系我们 | 会员服务 | 广告服务 | 友情链接 |
版权所有 CopyRight © 2008-2024 粤ICP备08119708号