产品说明
一般描述
Reagent-cartridge CRBN-PEG2 is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.
Scale: up to 0.1 mmol
Linker: PEG2
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: amine
Compatible substrates: ketone, aldehyde
Cartridge contents:
- Reducing agent (supported cyanoborohydride)
- Base (supported triethylamine)
- SCX (for purification)
- Degrader building block linker reagent
Related Cartridges:
- SYNPLE-P001Reagent-cartridge CRBN-PEG1
- SYNPLE-P003Reagent-cartridge CRBN-PEG3
- SYNPLE-P004Reagent-cartridge CRBN-PEG4
- SYNPLE-P005Reagent-cartridge CRBN-PEG5
- SYNPLE-P021Reagent-cartridge VHL-PEG1
- SYNPLE-P022Reagent-cartridge VHL-PEG2
- SYNPLE-P023Reagent-cartridge VHL-PEG3
- SYNPLE-P024Reagent-cartridge VHL-PEG4
- SYNPLE-P025Reagent-cartridge VHL-PEG5
Learn more about the Synple automated synthesis platform.
Learn more more about protein degradation.
Explore all our Protein Degrader Building Blocks
Features and Benefits of Synple Platform
- Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization
- Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
- Safety - all chemicals are contained in the system, minimizing the user′s exposure
- Set-up reaction in less than 5 minutes
- Small footprint
- Plug & Play system - simple installation
- Reaction temperatures from 25 ℃ - 80 ℃
- Cartridges available for many different reactions
- Prefilled with all required reagents
- RFID chip containing optimized reaction protocol
其他说明
An integrated console for capsule-based, automated organic synthesis
法律信息
Product of Synple Chem AG
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
产品性质
| 质量水平 | 100 |
安全信息
| 象形图 |  |
| 警示用语： | Warning |
| 危险声明 | H315 - H319 |
| 预防措施声明 | P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313 |
| 危险分类 | Eye Irrit. 2 - Skin Irrit. 2 |
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
