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Nω-Hydroxy-nor-L-arginine, Diacetate Salt-CAS 189302-40-7-Calbiochem

Nω-羟基-去甲-L-精氨酸,二醋酸盐-CAS 189302-40-7-Calbiochem

品牌
Sigma-Aldrich
CAS
189302-40-7
货号
399275
规格纯度
A potent, selective, competitive, and high affinity inhibitor of arginase.
参考价格
731.23 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Shown to specifically interact with the manganese-cluster of the enzyme active site. Does not function as a substrate or as an inhibitor for NOS. Hence, nor-NOHA may be a useful tool to study the interplays between arginase and NOS.
A potent, selective, competitive, and high affinity inhibitor of arginase. Shown to inhibit arginase from rat liver (IC50 = 2 µM) and mouse macrophages (IC50 = 50 µM). Specifically interacts with the manganese-cluster of the enzyme active site. Does not act as a substrate or as an inhibitor of NOS. Hence, it may serve as a useful tool to study the interplays between arginase and NOS.

包装

1, 5 mg in Plastic ampoule
Packaged under inert gas

生化/生理作用

Primary Target
arginase from rat liver
Secondary Target
mouse macrophages (IC₅₀ = 50 µM)

警告

Toxicity: Standard Handling (A)

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他说明

Gobert, A.P., et al. 2000. Infect. Immun. 68, 4653.
Meurs, H., et al. 2000. Br. J. Pharmacol. 130, 1793.
Moali, C., et al. 2000. Biochemistry 39, 8208.
Tenu, J.P. et al. 1999. Nitric Oxide 3, 427.
Moali, C., et al. 1998. Biochemistry 37, 10453.
Custot, J., et al. 1997. J. Am. Chem. Soc. 119, 4086.

法律信息

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

基本信息

经验(实验)分子式C5H12N4O3 · 2C2H4O2
分子量296.28

产品性质

质量水平100
测定≥97% (TLC)
形式solid
效能2 μM IC50
manufacturer/tradenameCalbiochem®
储存条件OK to freeze
desiccated (hygroscopic)
颜色 off-white
溶解性water: 50 mg/mL
运输ambient
储存温度−20℃

安全信息

储存分类代码11 - Combustible Solids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

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