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Trimethoprim Ready Made Solution

品牌
Sigma-Aldrich
货号
SBR00024
规格纯度
25 mg/mL in DMSO
参考价格
775.07 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

应用

Trimethoprim is used at a final concentration of ~4μg/mL for antibacterial activty.

生化/生理作用

Trimethoprim is a synthetic derivative of pyrimidine with antibacterial and antiprotozoal properties. Trimethoprim is an inhibitor of bacterial dihydrofolate reductase (DHFR), interfering with the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF). THF is an essential precursor in the thymidine synthesis pathway, interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim′s affinity for bacterial DHFR is several thousand times greater than its affinity for human DHFR. Trimethoprim is potentiated by Sulfonamides and the Trimethoprim-sulfamethazole combination is the most used form.

基本信息

经验(实验)分子式C14H18N4O3
分子量290.32

产品性质

生物来源synthetic
测定≥98% (HPLC)
形式liquid
浓度25 mg/mL in DMSO
作用机制DNA synthesis | interferes
enzyme | inhibits
抗生素抗菌谱Gram-negative bacteria
Gram-positive bacteria
mycobacteria
储存温度−20℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 2
闪点(F)188.6 °F
闪点(C)87 ℃

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