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Phospho-EGFR (pSer1070) ELISA Kit

磷酸化EGFR(pSer 1070)ELISA试剂盒

品牌
Sigma-Aldrich
货号
RAB0161
规格纯度
for detection of human, mouse or rat phospho-egfr (pSer1070) in cell and tissue lysates
参考价格
7898.7 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The Human BLC ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human BLC in serum, plasma, cell culture supernatants and urine.
The EGFR (epidermal growth factor receptor) family includes four receptor tyrosine kinases, EGF R (ErbB1), ErbB2 (neu), ErbB3, and ErbB4. EGF R is present on many cell types of epithelial and mesenchymal lineages. The gene EGFR is mapped to human chromosome 7p11.2.

免疫原

EGFR (pTyr1070) synthetic phosphopeptide

应用

请参考Protocol了解详情。

生化/生理作用

The members of epidermal growth factor receptor (EGF R) or the ErbB receptor family have been identified as useful biomarkers and targets for cancer therapy. EGF R binds EGF and induces tyrosine phosphorylation leading to proliferation of cells. EGF R is capable of binding transforming growth factor-α and heparin-binding EGF in addition to EGF. There are numerous effector molecules activated by EGF R that result in a variety of biological processes such as morphogenesis, cell motility, apoptosis, differentiation and organ repair and maintenance. Deregulation of EGF R signaling is implicated in progression of a wide variety of tumors, invasion and metastasis. Phosphorylation of Tyr1068 occurs by autophosphorylation of EGF R and is required for the binding of Grb2 (Growth factor receptor-bound protein 2) and activation of ERK1/2 (extracellular signal-regulated kinases) pathway.

基本信息

NACRESNA.32

产品性质

species reactivityrat, human, mouse
technique(s)ELISA: suitable
capture ELISA: suitable
inputsample type cell lysate
sample type tissue lysate
运输wet ice
储存温度−20℃
Gene Informationhuman ... EGFR(1965)

安全信息

象形图GHS05GHS07
警示用语:Warning
危险声明H290 - H335
危险分类Met. Corr. 1 - STOT SE 3
靶器官Respiratory system
储存分类代码8B - Non-combustible, corrosive hazardous materials

Sigma-Aldrich

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