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Ingenol-3-angelate

品牌
Sigma-Aldrich
CAS
75567-37-2
货号
SML1318
包装型号
规格纯度
≥95% (HPLC)
参考价格
1677 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

包装

1 mg in glass bottle

生化/生理作用

Ingenol-3-angelate, is a phorbol ester-like compound or a diacylglycerol analog that is used in the treatment of several disorders like skin cancer. It is also known as PEP005. Ingenol-3-angelate stimulates the initiation of the enzyme by providing PKCs (protein kinase C) to cellular membranes.
Ingenol 3-Angelate is a diterpenoid ester isolated from Euphorbia peplus that induces rapid cell death with keratinocytes and some cancer cell lines. Ingenol 3-Angelate is a protein kinase C activator that displays potent antileukemic activity. Ingenol 3-Angelate (ingenol mebutate) is used for treatment of actinic keratosis.

基本信息

经验(实验)分子式C25H34O6
分子量430.53
PubChem化学物质编号329825782
NACRESNA.77

产品性质

生物来源semisynthetic
质量水平100
测定≥95% (HPLC)
形式powder
颜色 white to beige
溶解性DMSO: 15 mg/mL, clear
储存温度−20℃
SMILES stringO=C1[C@@]2(C=C(C)[C@@H]3OC(/C(C)=C\C)=O)[C@]3(O)[C@H](O)C(CO)=C[C@@]1([H])[C@@](C4(C)C)([H])[C@@]4([H])C[C@H]2C
InChI1S/C25H34O6/c1-7-12(2)22(29)31-21-13(3)10-24-14(4)8-17-18(23(17,5)6)16(20(24)28)9-15(11-26)19(27)25(21,24)30/h7,9-10,14,16-19,21,26-27,30H,8,11H2,1-6H3/b12-7-/t14-,16+,17-,18+,19-,21+,24+,25+/m1/s1
InChI keyVDJHFHXMUKFKET-WDUFCVPESA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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