产品说明
一般描述
HepaRG is a human hepatoma cell line. The cells possess a pseudodiploid karyotype and have been characterized as an oval ductular bipotent hepatic cell line as they have the ability to differentiate into both biliary and hepatocyte lineages in the presence of DMSO. HepaRG PERK knockout cells express the major xenobiotic sensors (PXR, CAR and AhR), drug transporters, phase I and II drug metabolizing enzymes as well as key hepatic transcription factors involved in stress response pathways.
应用
See technical bulletin for detailed protocols
特点和优势
HepaRG cells are the most metabolically active human hepatocyte cell line developed to date. These the cells are suitable for a wide variety of studies for drug metabolism, CYP induction, metabolism-mediated toxicity, transporter, and hepatotoxicity. - Sigma′s HepaRG PERK Knockout (KO) allows investigations of Wolcott-Rallison syndrome and endoplasmic reticulum stress response involving PERK in the liver.
质量
Tested for Mycoplasma, sterility, post-freeze viability, short terminal repeat (STR) analysis for cell line identification, cytochrome oxidase I (COI) analysis for cell line species confirmation.
法律信息
Exhibit 1: ADME/Tox cell lines license
Exhibit 2: HepaRG limited use license
HepaRG is a trademark of BioPredic International company
基本信息
| NACRES | NA.81 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human female liver (hepatocarcinoma and hepatitis C tumor) |
| 形式 | liquid |
| OMIM登记号 | 604032 |
| 储存温度 | −196℃ |
| Gene Information | human ... EIF2AK3(9451) |
安全信息
| 储存分类代码 | 12 - Non Combustible Liquids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
