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desmosterol-d6

品牌
Avanti
CAS
1246298-67-8
货号
700040P
规格纯度
cholesta-5,24-dien-3β-ol-d6, powder
参考价格
4213.19 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Desmosterol constitutes 1% of brain sterol and is catabolized to cholesterol by the enzyme 3-hydroxysterol 24-reductase (DHCR24). It is an intermediate in the Bloch branch of the cholesterol biosynthesis pathway. Desmosterol-d6 is a deuterated form of desmosterol.

应用

Desmosterol-d6 has been used:

  • as a deuterated standard in liquid chromatography multiple reaction monitoring (LC-MRM)
  • as a deuterated standard in high-performance liquid chromatography/electrospray ionization tandem mass spectrometry (HPLC-ESI-MS)
  • for spiking brain tissue homogenate from Alzheimer′s disease (AD) for liquid chromatography -mass spectrometry (LC-MS) analysis

生化/生理作用

Desmosterol low levels in the hippocampus directly impacts progenitor cell differentiation into neurons. Desmosterol-d6 is used as a substitute to desmosterol in hepatitis C virus (HCV) based viral assays to rescue replication. Desmosterol being a C27 sterol intermediate is implicated in the Alzheimer′s disease (AD) pathogenesis.

包装

5 mL Amber Glass Screw Cap Vial (700040P-1mg)

基本信息

经验(实验)分子式C27H38OD6
分子量390.67
NACRESNA.25

产品性质

测定>99% (TLC)
形式powder
包装pkg of 1 × 1 mg (700040P-1mg)
manufacturer/tradenameAvanti Polar Lipids 700040P
运输dry ice
储存温度−20℃

安全信息

储存分类代码13 - Non Combustible Solids

Sigma-Aldrich

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