产品说明
一般描述
Cholestenoic acid-d5 is an endogenous cholesterol metabolite. It is produced in extrahepatic organs.
Cholestenoic acid levels in plasma ranges between 100-300 nM and is synthesized in brain. Cholestenoic acid is generated by the side chain oxidation of 27-hydroxy-cholesterol and is an intermediate in the bile synthesis pathway.
生化/生理作用
Cholestenoic acid-d5 functions as a potent steroid γ-secretase modulator (GSM).
Cholestenoic acid is a carboxylic acid γ-secretase modulator. Cholestenoic acid also serves as a ligand for liver X receptor. Cholestenoic acid -d5 regulates amyloid β peptides (Aβ) levels. It reduces Aβ42 levels and enhances Aβ38 levels. In retina, it is the major byproduct of cholesterol elimination. 27-hydroxycholesterol and cholestenoic acid are part of reverse cholesterol transport in macrophages and their transport impairment is implicated in premature atherosclerosis.
包装
5 mL Amber Glass Screw Cap Vial (700151P-1mg)
基本信息
| 经验(实验)分子式 | C27H39 D5O3 |
| 分子量 | 421.67 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (TLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 1 mg (700151P-1mg) |
| manufacturer/tradename | Avanti Polar Lipids 700151P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
