产品说明
一般描述
Lysophosphatidic acid (LPA) is a class of phospholipids, which is water-soluble. It has a glycerol backbone attached via a phosphate group, an aliphatic chain and a hydroxyl group. The aliphatic chain is linked to either sn-1 or sn-2 position and the phosphate group is connected to the sn-3 position. The hydroxyl group is linked to the remaining sn-1 or sn-2 position.
应用
C18 LPA or 1-O-octadecyl-2-hydroxy-sn-glycero-3-phosphate may be used:
- to study its effects on Yes-associated protein (YAP) phosphorylation
- as a standard for the quantification of lysophosphatidic acid (LPA) compounds in proton samples using reversed-phase ultra-performance liquid chromatography-tandem mass spectrometer (UPLC-MS/MS)
- as a substrate to investigate the phosphatase activity of soluble epoxide hydrolase (sEH) towards LPA compounds
生化/生理作用
Lysophosphatidic acid (LPA) is a signaling molecule and alters various cellular responses through G protein-coupled receptors (GPCRs). It stimulates smooth muscle contraction, cytoskeleton rearrangement and chemotaxis. LPA is also involved in inducing neurotransmitter release, cell proliferation, platelet aggregation and Ca2+ mobilization. Increased levels of LPA in human plasma leads to ovarian cancer and atherosclerosis. LPA acts as a potential biomarker for ovarian cancer.
包装
5 mL Amber Glass Screw Cap Vial (857228P-1mg)
基本信息
| 经验(实验)分子式 | C21H48NO6P |
| 分子量 | 441.58 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (LPA; may contain up to 10% of the 2-LPA isomer) |
| 形式 | powder |
| 包装 | pkg of 1 × 1 mg (857228P-1mg) |
| manufacturer/tradename | Avanti Polar Lipids 857228P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | O[C@](COP([O-])(O)=O)([H])COCCCCCCCCCCCCCCCCCC.[NH4+] |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
