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Activated Protein C (APC) Inhibitor Screening Kit

品牌
Sigma-Aldrich
货号
MAK346
规格纯度
sufficient for 100 colorimetric tests
参考价格
7475.28 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Activated protein C (APC), a Vitamin K dependent serine protease, is formed by activation of Protein C by Thrombomodulin bound on the surface of endothelial cells. By degrading coagulation factors Va and VIIIa, APC inhibits blood coagulation which helps in the prevention of thrombosis. Blood coagulation can be stimulated by inhibition of APC. Thus, APC inhibitors play an important role in the treatment of disease like Haemophilia.

特点和优势

Compatible with high-throughput handling systems.

适用性

Suitable for screening and characterizing inhibitors/ligands of APC

原理

The Activated Proctein C (APC) Inhibitor Screening Kit can be used to screen for potent inhibitors of APC activity. It utilizes the proteolytic activity of an active APC on a peptide substrate which releases a colored product. The released product can be easily quantified using an absorbance microplate reader. In the presence of an APC inhibitor, the enzyme decreases/loses activity resulting in lower/no absorbance. 

产品性质

用途 sufficient for 100 colorimetric tests
detection methodcolorimetric

安全信息

储存分类代码10 - Combustible liquids
闪点(F)188.6 °F
闪点(C)87 ℃

Sigma-Aldrich

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