产品说明
一般描述
1-desoxymethylsphingosine is synthesized from glycine in the presence of the enzyme serine palmitoyltransferase (SPT).
应用
1-desoxymethylsphingosine may be used for the complex preparation with bovine serum albumin for cytotoxicity testing in MN9D dopaminergic neuroblastoma cell line.
生化/生理作用
1-desoxymethylsphingosine is less neurotoxic compared to 1-desoxysphingosine in dorsal root ganglion neuronscultures Mutations in the palmitoyltransferase (SPT) in hereditary sensory neuropathy type 1 (HSAN-1), due to altered substrate specificity 1-desoxymethylsphinganine and 1-deoxy-sphinganine which are further converted to -deoxy(methyl)-ceramide and 1-deoxy(methyl)-sphingosine (1-deoxy(methyl)-SO). However, they lack the hydroxyl group essential for glycosphingolipid generation, resulting in accumulation of intermediate products.
包装
5 mL Amber Glass Screw Cap Vial (860477P-1mg)
基本信息
| 经验(实验)分子式 | C17H35NO |
| 分子量 | 269.47 |
| NACRES | NA.25 |
产品性质
| 形式 | powder |
| 包装 | pkg of 1 × 1 mg (860477P-1mg) |
| manufacturer/tradename | Avanti Polar Lipids 860477P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | CCCCCCCCCCCCC/C=C/[C@](O)([H])CN |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
