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Nogo-66(1-40) antagonist peptide

品牌
Sigma-Aldrich
货号
N7161
包装型号
规格纯度
≥84% (HPLC)
参考价格
7175.45 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

Amino Acid Sequence

Arg-Ile-Tyr-Lys-Gly-Val-Ile-Gln-Ala-Ile-Gln-Lys-Ser-Asp-Glu-Gly-His-Pro-Phe-Arg-Ala-Tyr-Leu-Glu-Ser-Glu-Val-Ala-Ile-Ser-Glu-Glu-Leu-Val-Gln-Lys-Tyr-Ser-Asn-Ser-NH2

应用

Nogo-66(1-40) antagonist peptide has been used as a Nogo-66 receptor antagonist peptide:

  • to study the preliminary therapeutic effect after inhibition of Nogo-A in the cauda equina compression (CEC) model
  • to determine the effects of Nogo-A/NgR1 on autophagic activation
  • to study its role in Nogo-B mediated axonal branching using Schwann cells and sensory neurons of mice

包装

1 mg in glass bottle

生化/生理作用

Myelin-derived axon outgrowth inhibitors, such as Nogo, may account for the lack of axonal regeneration in the central nervous system (CNS) after trauma in adult mammals. Nogo-66 can inhibit axonal outgrowth through an axonal Nogo-66 receptor (NgR). Competitive antagonists of NgR derived from amino-terminal peptide fragments of Nogo-66. The Nogo-66(1 40) antagonist peptide (NEP1 40) blocks Nogo-66 or CNS myelin inhibition of axonal outgrowth in vitro, demonstrating that NgR mediates a significant portion of axonal outgrowth inhibition by myelin. Intrathecal administration of NEP1 40 to rats with mid-thoracic spinal cord hemisection results in significant axon growth of the corticospinal tract, and improves functional recovery. Thus, Nogo-66 and NgR have central roles in limiting axonal regeneration after CNS injury, and NEP1-40 provides a potential therapeutic agent.

法律信息

Sold under a non-exclusive license. For research use only, and not for diagnostic or therapeutic use or for use in humans.

基本信息

经验(实验)分子式C204H322N56O64 · xC2HF3O2
分子量4583.08 (free base basis)
MDL编号MFCD06411437
NACRESNA.32

产品性质

质量水平100
测定≥84% (HPLC)
形式lyophilized solid
颜色 white
溶解性H2O: 1 mg/mL
UniProt登记号Q9NQC3
储存温度−20℃
Gene Informationhuman ... RTN4(57142)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

Sigma-Aldrich

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