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Factor IXa Activity Assay Kit (Fluorometric)

Factor Ixa活性检测试剂盒(荧光法)

品牌
Sigma-Aldrich
货号
MAK240
规格纯度
sufficient for 100 fluorometric tests
参考价格
5889.65 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The coagulation Factor IX (or Christmas factor) (EC 3.4.21.22) is a vitamin K-dependent serine protease. Factor IX is produced as an inactive precursor and is activated via cleavage by either factor XIa (contact pathway) or factor VIIa (tissue factor pathway). In the presence of calcium ions and negatively charged membrane phospholipids, activated factor IX (FIXa) then binds to the activated Factor VIII (FVIIIa) and proteolytically activates factor X (FX) to factor Xa (FXa). Deficiency in factor IX causes hemophilia B, an X-linked bleeding disorder.

适用性

Suitable to determine the activity of purified Factor IX and to detect the activity of Factor IX in plasma and serum.

原理

This Factor IXa Activity Assay kit is based on the ability of FIXa to generate FXa. The generated FXa proteolytically cleaves a synthetic substrate and releases a fluorophore, AMC, which can be easily quantified by fluorescence microplate reader. The assay is simple, rapid, and can detect activity as low as 10 pg of FIXa in a variety of samples.

基本信息

NACRESNA.84

产品性质

detection methodfluorometric
储存温度−20℃

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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