产品说明

一般描述

A Protein Conformational Array (PCA) in a sandwich ELISA format where the plate is coated with a panel of antibodies raised against peptides derived from the full length protein sequence of Alemtuzumab. Taken individually, each of these antibodies is strongly antigenic to the peptide sequence that was used in its production. However, when these peptides are incorporated into a full length correctly folded protein, the antigenicity of many of them is masked by the three dimensional structure of the protein and only a limited number of the antibodies respond. The result is a histogram which can be likened to a ′fingerprint′ for correctly folded Alemtuzumab. For a Campath Biosimilar, if the protein is correctly folded and glycosylated, the ′fingerprint′ will match that of Alemtuzumab. If it is not correctly folded, previously masked peptide sequences will be exposed and will be recognized by the antibody made to that exposed sequence. In this way, changes in the ′fingerprint′ generated by the ELISA will point out differences between the Biosimilar and authentic Alemtuzumab.

应用

For research use only. Not for use in diagnostic procedures.

基本信息

产品性质

安全信息

象形图
警示用语：	Warning
危险声明	H290 - H315 - H319
预防措施声明	P305 + P351 + P338
危险分类	Eye Irrit. 2 - Met. Corr. 1 - Skin Irrit. 2