产品介绍：
产品说明
一般描述
7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.
应用
7β-hydroxycholesterol-d7 has been used:
- as cholesterol oxidation product for mass spectroscopy analysis
- as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
- as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
- as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification
生化/生理作用
7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.
包装
5 mL Amber Glass Screw Cap Vial (700044P-1mg)
基本信息
| 经验(实验)分子式 | C27H39O2D7 |
| 分子量 | 409.70 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (TLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 1 mg (700044P-1mg) |
| manufacturer/tradename | Avanti Polar Lipids 700044P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
