产品说明
一般描述
27-hydroxycholesterol (27-HC) is synthesized from cholesterol by the action of sterol 27-hydroxylase in the liver. It is an abundant oxysterol in the circulation ranging from 0.15 to 0.73 μM. 27-HC serves as a substrate for bile synthesis. 27-hydroxycholesterol-d6 is a deuterated form of 27-hydroxycholesterol.
应用
27-hydroxycholesterol-d6 has been used:
- as an internal standard in isotope dilution-mass spectrometry analysis of heart mitochondria samples
- as an internal standard in gas chromatography-mass spectrometry (GC–MS) for plasma sterol quantification
- as a deuterated internal standard for spiking plasma samples for liquid chromatography with tandem mass spectrometry (LC-MS-MS) analysis
生化/生理作用
27-hydroxycholesterol (27-HC) is a weak liver X receptor (LXR) agonist and a selective estrogen receptor modulator (SERM). Elevated levels of 27-HC is observed in hypercholesterolemia. 27-HC is implicated in breast cancer tumor and glioblastoma progression. 27-HC may help in treating non-alcoholic steatohepatitis. Elevated levels of 27-HC is associated with atherosclerotic lesions.
包装
5 mL Amber Glass Screw Cap Vial (700059P-1mg)
基本信息
| 经验(实验)分子式 | C27H40D6O2 |
| 分子量 | 408.69 |
| NACRES | NA.25 |
产品性质
| 测定 | >99% (TLC) |
| 形式 | powder |
| 包装 | pkg of 1 × 1 mg (700059P-1mg) |
| manufacturer/tradename | Avanti Polar Lipids 700059P |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=CC2)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCC[C@@]([2H])(C([2H])([2H])[2H])C(O)([2H])[2H] |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | No data available |
| 闪点(C) | No data available |
