产品介绍：
产品说明
Amino Acid Sequence
Z-Ile-Glu-OMe-Thr-Asp-OMe-FMK
应用
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) has been used as a caspase-8 inhibitor:
- to study the activity of caspase-8 in porcine kidney cells
- to study its effects on porcine parvovirus (PPV)-induced caspase-3 activity in steroidogenic luteal cells
- to study its effects on retinal ganglion and astroglia in rat eyes
生化/生理作用
Z-Ile-Glu(O-ME)-Thr-Asp(O-Me) fluoromethyl ketone (Z-IETD-FMK) is an irreversible and cell-permeable caspase-8 inhibitor.
特点和优势
This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
基本信息
| 经验(实验)分子式 | C30H43FN4O11 |
| 分子量 | 654.68 |
| MDL编号 | MFCD01861686 |
| PubChem化学物质编号 | 329774744 |
| NACRES | NA.77 |
产品性质
| 质量水平 | 200 |
| 生物来源 | synthetic (organic) |
| 测定 | ≥90% (TLC) |
| 形式 | powder |
| 溶解性 | methanol: 10 mg/mL DMSO: 20 mM, clear, colorless to light yellow |
| 运输 | dry ice |
| 储存温度 | −20℃ |
| SMILES string | CC[C@H](C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)O)C(=O)N[C@@H](CC(O)=O)C(=O)CF |
| InChI | 1S/C28H39FN4O11/c1-4-15(2)23(33-28(43)44-14-17-8-6-5-7-9-17)26(41)30-18(10-11-21(36)37)25(40)32-24(16(3)34)27(42)31-19(12-22(38)39)20(35)13-29/h5-9,15-16,18-19,23-24,34H,4,10-14H2,1-3H3,(H,30,41)(H,31,42)(H,32,40)(H,33,43)(H,36,37)(H,38,39)/t15-,16+,18-,19-,23-,24-/m0/s1 |
| InChI key | CTXDBLYOEUERAT-VUVYEONESA-N |
安全信息
| 储存分类代码 | 13 - Non Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | Eyeshields, Gloves, type N95 (US) |
