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Skyrin

品牌
Sigma-Aldrich
CAS
602-06-2
货号
SML0459
规格纯度
≥98% (HPLC), from Penicillium islandicum
参考价格
4301.36 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

生化/生理作用

Skyrin is a non-peptidic anthraquinone, mycotoxin with in vitro cytotoxic activity. It suppresses the growth of HeLa, Vero, K562, Raji, Wish and Calu-1 cell lines. Skyrin treatment induces DNA fragmentation and other morphological changes leading to apoptosis in Human HL-60 promyelotic leukemia cells. Skyrin was found to serve as an anti-diabetic agent by selectively binding to the glucagon receptor acting as its antagonist. Regular binding of glucagon to its receptor on hepathocyte plasma membrane activates adenylate cyclase indirectly. As a result, the cAMP produced activates protein kinase A with a consequent increase in both glycogen breakdown and gluconeogenesis leading to glucose output. Skyrin was shown to block this signal transduction sequence, such that the interaction of glucagons with its receptor does not result in an increase in cAMP production. Skyrin was also found to efficiently scavenge free radical species as OH,R and of singlet oxygen (1O2). Based on Skyrin selective toxicity towards insect cell line Sf9, it may be useful as an agent for pest control.

基本信息

经验(实验)分子式C30H18O10
分子量538.46
NACRESNA.77

产品性质

质量水平200
生物来源Penicillium islandicum
测定≥98% (HPLC)
储存条件protect from light
溶解性DMSO: soluble
acetone: soluble
ethyl acetate: soluble
储存温度−20℃
InChI1S/C30H18O10/c1-9-3-11-19(13(31)5-9)29(39)23-17(35)7-15(33)21(25(23)27(11)37)22-16(34)8-18(36)24-26(22)28(38)12-4-10(2)6-14(32)20(12)30(24)40/h3-8,31-36H,1-2H3
InChI keyMQSXZQXHIJMNAF-UHFFFAOYSA-N

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable

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