产品说明
一般描述
Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS).
应用
Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays.
生化/生理作用
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis.
Determined using polyclonal and monoclonal antibodies against MBP.
外形
Lyophilized from 10mM HCl.
其他说明
Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV.
基本信息
| MDL编号 | MFCD03457654 |
| NACRES | NA.32 |
产品性质
| 质量水平 | 200 |
| 生物来源 | human brain |
| 测定 | ≥95% (SDS-PAGE) |
| 形式 | lyophilized powder |
| technique(s) | ELISA: suitable |
| UniProt登记号 | P02686 |
| 储存温度 | −20℃ |
| Gene Information | human ... MBP(4155) |
安全信息
| 储存分类代码 | 11 - Combustible Solids |
| WGK | WGK 3 |
| 闪点(F) | Not applicable |
| 闪点(C) | Not applicable |
| 个人防护装备 | dust mask type N95 (US), Eyeshields, Gloves |
