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CD152/Fc Chimera, Non-cytolytic from mouse

品牌
Sigma-Aldrich
货号
C4358
规格纯度
≥98% (SDS-PAGE), recombinant, expressed in NS.1 cells, lyophilized
参考价格
7883.47 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

The extracellular domain (160 amino acids) of mouse CD152 is fused to mouse IgG2a Fc domain in which mutations to the complement (C1q) and FcγR I binding sites of the Fcγ2a fragment render the Fc fusion protein incapable of direct antibody directed cytotoxicity (ADCC) and complement directed cytotoxicity (CDC).

生化/生理作用

CD152 (CTLA4), a cell surface glycoprotein expressed at low levels on activated T cells, is a high affinity receptor for the costimulatory molecules CD80 (B7-1) and CD86 (B7-2). A related cell surface glycoprotein, CD28, binds to CD80 and CD86 with lower affinity. The soluble CD152/Fc chimeric fusion protein blocks the B7/CD28 signaling pathway by binding to CD80 and CD86.

外形

Lyophilized from solution of 0.2 μm filtered, in phosphate buffered saline, pH 7.4, with no preservative added.

制备说明

Purified from serum-free tissue culture supernatant

基本信息

MDL编号MFCD01092888
NACRESNA.32

产品性质

质量水平200
重组expressed in NS.1 cells
测定≥98% (SDS-PAGE)
形式lyophilized
分子量 97 kDa
UniProt登记号P09793
运输wet ice
储存温度−20℃
Gene Informationmouse ... Ctla4(12477)

安全信息

储存分类代码13 - Non Combustible Solids
WGKWGK 3
闪点(F)Not applicable
闪点(C)Not applicable
个人防护装备Eyeshields, Gloves, type N95 (US)

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