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Anti-Interleukin-4 Soluble Receptor antibody produced in goat

品牌
Sigma-Aldrich
货号
I6527
规格纯度
IgG fraction of antiserum, lyophilized powder
参考价格
4731.57 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

Interleukin-4 (IL-4) is a T cell derived chemokine that stimulates the Th2 mediated immune response and proliferation of B cells. The effects of IL-4 are mediated by two types of receptors, type I receptor consisting of IL-4Rα and common γ chain and type II receptor composed of IL-4Rα and IL-13Rα1. The signalling stimulated by IL-4R leads to activation of JAK/STAT6 and IRS-mediated PI3K/Akt pathway. Through these pathways, IL-4 is responsible for endocytic activity of macrophages, chemotaxis of leukocytes in response to inflammation, angiogenesis and regulation of nitric oxide metabolism in macrophages. Anti-tumor effects of IL-4R signaling have been reported in cancers of breast, liver and renal cells
Anti-Interleukin-4 soluble receptor specifically recognizes human cell surface IL-4R.

特异性

The antibody will neutralize human cell surface IL-4 receptor mediated-bioactivity.

免疫原

recombinant human IL-4 soluble receptor (IL-4 sR), expressed in Sf 21 insect cells.

应用

Anti-Interleukin-4 soluble receptor antibody may be used for immunoblotting at a working concentration of 1-2 μg/ml. For ELISA, a working concentration of 0.5-1.0 μg/ml is recommended. The antibody is suitable for neutralization reactions at a working concentration of 5-10 μg/ml. This antibody was used for immunostaining of parasympathetic neurons from guinea pig and human neuroblastoma cells at a dilution of 1:200.

外形

Lyophilized from 51.5 μL of a 0.2μm filitered solution in PBS (pH7.4) with 5% trehalose.

制备说明

Purified using Protein G.

基本信息

MDL编号MFCD02096774
NACRESNA.41

产品性质

质量水平100
生物来源goat
偶联物unconjugated
抗体形式IgG fraction of antiserum
antibody product typeprimary antibodies
克隆polyclonal
形式lyophilized powder
species reactivityhuman
technique(s)indirect ELISA: suitable
neutralization: suitable
western blot: suitable
UniProt登记号P24394
储存温度−20℃
Gene Informationhuman ... IL4R(3566)

安全信息

储存分类代码10 - Combustible liquids
WGKWGK 1
闪点(F)Not applicable
闪点(C)Not applicable

Sigma-Aldrich

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