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Anti-GABAA Receptor (β1 subunit), Cytosolic Loop antibody produced in rabbit

Anti-γ-Aminobutyric Acid Type A Receptor (β1 subunit)

品牌
Sigma-Aldrich
货号
G9419
规格纯度
~0.2 mg/mL, affinity isolated antibody, buffered aqueous glycerol solution
参考价格
6162.13 *本价格含增值税费
促销
数量
-+
产品介绍:

产品说明

一般描述

GABAA and GABAB receptors differ with regard to their ionic characteristics and pharmacological properties. The GABAA receptor is an ionotropic receptor that forms the GABA gated chloride channel and consists of several heterogeneous subunits with membrane recognition sites for benzodiazapenes. GABAA receptor is a ligand-gated chloride channel that is a multimeric subunit complex. So far, around 16 subunits have been identified. This gene encodes the β1 subunit, which maps to human chromosome 4p12. It is present in a cluster along with genes encoding α 4, α 2 and γ 1 subunits of the GABA A receptor.

免疫原

fusion protein with the amino acid sequence representing the cytosolic loop of the rat GABAA receptor (β1 subunit)

应用

Anti-GABAA Receptor (β1 subunit), Cytosolic Loop antibody produced in rabbit is suitable for western blotting at a working dilution of 1:1000 using rat membrane fraction.

生化/生理作用

The inhibitory neurotransmitter GABA signals through two distinct types of pre- and postsynaptic receptors, GABAA and GABAB. Both GABA receptors can regulate depression of synaptic transmission and be involved in the inhibition controlling neuronal excitability. Disruption in this receptor is implicated in autism. Alterations in N-glycosylation of α1, β1, and β2 have been observed in schizophrenic patients.

外形

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA, and 50% glycerol

免责声明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

基本信息

MDL编号MFCD07370322
NACRESNA.41

产品性质

生物来源rabbit
质量水平200
偶联物unconjugated
抗体形式affinity isolated antibody
antibody product typeprimary antibodies
克隆polyclonal
形式buffered aqueous glycerol solution
用途 sufficient for 10 blots
分子量antigen apparent mol wt 51-54 kDa
species reactivityrat
浓度~0.2 mg/mL
technique(s)western blot: 1:1,000 using rat membrane fraction
UniProt登记号P15431
运输wet ice
储存温度−20℃
Gene Informationrat ... Gabrb1(25450)

Sigma-Aldrich

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